Publications

2020

Olgac A., Carotti A., Kretzer C., Zergiebel S., Seeling A., Garscha U., Werz O., Macchiarulo A., Banoglu, E. Discovery of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by Exploiting a Multistep Virtual Screening Protocol. J. Chem. Inf. Model., 60(3), 1737-1748, 2020.  Click to see

Akbulut O., Lengerli D., Saatci O., Duman E., Seker U. O. S., Isik A., Akyol A., Caliskan B., Banoglu E., Sahin, O. A Highly Potent TACC3 Inhibitor as a Novel Anticancer Drug Candidate. Mol. Cancer Ther., 19(6):1243-1254, 2020. Click to see

Uslu A.G., Gür Maz T., Nocentini A., Banoglu, E., Supuran C.T., Çalıskan, B. Benzimidazole Derivatives as Potent and Isoform Selective Tumor-Associated Carbonic Anhydrase IX/XII Inhibitors. Bioorg. Chem., 95, 103544, 2020. Click to see

Shkodra-Pula B., Kretzer C., Jordan P. M., Klemm P., Koeberle A., Pretzel D., Banoglu E., Lorkowski S., Wallert M., Höppener S., Stumpf S., Vollrath A., Schubert S., Werz O, Schubert, U. S. Encapsulation of the Dual FLAP/mPEGS-1 Inhibitor BRP-187 Into Acetalated Dextran and PLGA Nanoparticles Improves Its Cellular Bioactivity. J. Nanobiotechnology, 18(1), 73, 2020. Click to see

Ozdemir A., Turanli S., Caliskan B., Ark M., Banoglu, E. Evaluation of Cytotoxic Activity of New Benzimidazole-Piperazine Hybrids Against Human MCF-7 and A549 Cancer Cells. (2020) Pharm. Chem. J., 53(11), 1036-1046, 2020. Click to see

Qneibi, M., Jaradat, N., Hawash, M., Olgac, A., & Emwas, N. Ortho versus Meta Chlorophenyl-2,3-Benzodiazepine Analogues: Synthesis, Molecular Modeling, and Biological Activity as AMPAR Antagonists. ACS Omega, 5(7), 3588-3595, 2020 Click to see 

Olgac, A., Yalcin, I., & Aki‐Yalcin, E. (2020). The 12th AFMC International Medicinal Chemistry Symposium (AIMECS 2019) in Istanbul, Turkey. ChemMedChem, 15(1), 162-167, 2020. Click to see

2019

Shekfeh S, Çalıskan B, Fischer K, Yalçın T, Garscha U, Werz O, Banoglu E. A Multi-step Virtual Screening Protocol for the Identification of Novel Non-acidic Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors. ChemMedChem, 14(2):273-281, 2019. Click to see

Boccellino M, Donniacuo M, Bruno F, Rinaldi B, Quagliuolo L, Ambruosi M, Pace S, De Rosa M, Olgaç A, Banoglu E, Alessio N, Massa A, Kahn H, Werz O, Fiorentino A, Filosa R. Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. Eur J Med Chem, 180, 637-647, 2019. Click to see

Mostarda S, Gür Maz T, Piccinno A, Cerra B, Banoglu E. Optimisation by Design of Experiment of Benzimidazol-2-One Synthesis Under Flow Conditions. Molecules, 24(13):2447, 2019. Click to see

Gur ZT, Senol FS, Shekfeh S, Orhan, IE, Banoglu E. Caliskan B. Novel Piperazine Amides of Cinnamic Acid Derivatives as Tyrosinase Inhibitors. Lett Drug Des Discov, 16(1), 36-44, 2019. Click to see

Najjar, A., Olğaç, A., Ntie-Kang, F., & Sippl, W. (2019). Fragment-based drug design of nature-inspired compounds. In F. Ntie-Kang (Ed.), Physical Sciences Reviews (Vol. 4). Click to see

Olğaç, A., Türe, A., Olğaç, S., & Möller, S. (2019). Cloud-Based High Throughput Virtual Screening in Novel Drug Discovery. In J. Kołodziej & H. González-Vélez (Eds.), High-Performance Modelling and Simulation for Big Data Applications: Selected Results of the COST Action IC1406 cHiPSet (pp. 250-278). Cham: Springer International Publishing.  Click to see

2018

Çalışkan B, Sinoplu E, İbiş K, Akhan Güzelcan E, Çetin Atalay R, Banoglu E. Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents. J Enzyme Inhib Med Chem, 33(1):1352-1361, 2018. Click to see

Bruno F, Errico S, Pace S, Nawrozkij MB, Mkrtchyan AS, Guida F, Maisto R, Olgaç A, D'Amico M, Maione S, De Rosa M, Banoglu E, Werz O, Fiorentino A, Filosa R. Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol- 3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation. Eur J Med Chem, 155, 946-960, 2018. Click to see

Aydin A, Akkurt M, Gur ZT, Banoğlu E. Crystal structure and Hirshfeld surface analysis of 1-(2,4-di-chloro-benz-yl)-5-methyl-N-(thio-phene-2-sulfon-yl)-1Hpyrazole- 3-carboxamide. Acta Crystallogr E Crystallogr Commun, 74(Pt 5), 747- 751, 2018. Click to see

Gür ZT, Çalışkan B, Garscha U, Olgaç A, Schubert US, Gerstmeier J, Werz O, Banoglu E. Identification of multi-target inhibitors of leukotriene and prostaglandin E2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7. Eur J Med Chem, 150:876-899, 2018. Click to see

Gür ZT, Çalışkan B, Banoglu E. Drug discovery approaches targeting 5- lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis. Eur J Med Chem,153, 34-48, 2018. Click to see

2017

Olğaç A, Orhan IE, Banoglu E. The potential role of in silico approaches to identify novel bioactive molecules from natural resources. Future Med Chem, 9(14), 1665-1686, 2017. Click to see

Orhan IE, Senol FS, Shekfeh S, Skalicka-Wozniak K, Banoglu E. Pteryxin - A promising butyrylcholinesterase-inhibiting coumarin derivative from Mutellina purpurea. Food Chem Toxicol, 109(Pt 2), 970-974, 2017. Click to see

2016

Banoglu E, Çelikoğlu E, Völker S, Olgaç A, Gerstmeier J, Garscha U, Çalışkan B, Schubert US, Carotti A, Macchiarulo A, Werz O. 4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP). Eur J Med Chem, 113, 1-10, 2016. Click to see

Garscha U, Voelker S, Pace S, Gerstmeier J, Emini B, Liening S, Rossi A, Weinigel C, Rummler S, Schubert US, Scriba GKE, Çelikoğlu E, Çalışkan B, Banoglu E. Sautebin L, Werz O. BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5- lipoxygenase-activating protein (FLAP) complex assembly. Biochem

Pharmacol, 119, 17-26, 2016. Click to see

Levent S, Gerstmeier J, Olgaç A, Nikels F, Garscha U, Carotti A, Macchiarulo A, Werz O, Banoglu E, Çalışkan B. Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7. Eur J Med Chem, 122, 510-519, 2016. Click to see

2014

Cankara Pirol S, Calışkan B, Durmaz I, Atalay R, Banoglu E. Synthesis and preliminary mechanistic evaluation of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid amides with potent antiproliferative activity on human cancer cell

lines. Eur J Med Chem. 87C,140-149, 2014. Click to see

Alaşalvar C, Soylu MS, Ünver H, Ocak İskeleli N, Yildiz M, Çiftçi M, Banoğlu E. Crystal structure and DFT calcu*lations of 5-(4-Chlorophenyl)-1-(6-methoxypyridazin-3-yl)-1H-pyrazole-3-carboxylic acid. Spectrochim Acta A Mol Biomol Spectrosc. 132, 555-62, 2014. Click to see

Baytas SN, Inceler N, Yilmaz A, Olgac A, Menevse S, Banoglu E, Hamel E, Bortolozzi R, Viola G. Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin

polymerization inhibitors. Bioorg Med Chem. 22(12), 3096-104, 2014. Click to see

Pergola C, Gerstmeier J, Mönch B, Çalışkan B, Luderer S, Weinigel C, Barz D, Maczewsky J, Pace S, Rossi A, Sautebin L, Banoglu E, Werz O. The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in

vivo by targeting 5-lipoxygenase-activating protein (FLAP). Br J Pharmacol. 171(12), 3051-64, 2014. Click to see

Sardella R, Levent S, Ianni F, Calişkan B, Gerstmeier J, Pergola C, Werz O, Banoglu E, Natalini B. Chromatographic separation and biological evaluation of benzimidazole derivative enantiomers as inhibitors of leukotriene

biosynthesis. J Pharm Biomed Anal. 89, 88-92, 2014. Click to see

2013

Levent S, Çalışkan B, Çiftçi M, Özkan Y, Yenicesu I, Ünver H, Banoglu E. Pyrazole derivatives as inhibitors of arachidonic acid-induced platelet aggregation. Eur J Med Chem. 64, 42-53, 2013. Click to see

Çalışkan B, Banoglu E. Overview of recent drug discovery approaches for new generation leukotriene A4 hydrolase inhibitors. Expert Opin. Drug Discov. 8(1), 49-63, 2013. Click to see

Çalışkan B, Yılmaz A, Evren I, Menevşe S, Uludag O, Banoglu E. Synthesis and evaluation of analgesic, anti-inflammatory, and anticancer activities of new pyrazole-3(5)-carboxylic acid derivatives. Med. Chem Res. 22, 782-793, 2013. Click to see

2012

Banoglu E, Çalışkan B, Luderer S, Eren G, Özkan Y, Altenhofen W, Weinigel C, Barz D, Gerstmeier J, Pergola C, Werz O. Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening

targeting 5-lipoxygenase-activating protein. Bioorg. Med. Chem. 20(12), 3728-3741, 2012. Click to see

Eren G, Macchiarulo A, Banoglu E. From Molecular docking to 3D-quantitative structure-activity relationships (3D-QSAR): Insights into the binding mode of 5-lipoxygenase inhibitors. Mol Inf. 32(2), 123-134, 2012. Click to see

2011

Çalışkan B, Luderer S, Özkan Y, Werz O, Banoglu E. Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils. Eur J Med Chem. 46(10), 5021-5033, 2011. Click to see

Çalıskan Ergün B, Çoban T, Kaynak Onurdag F, Banoglu E. Synthesis, antioxidant and antimicrobial evaluation of simple aromatic esters of ferulic acid. Arch Pharm Res. 34(8), 1251-1261, 2011. Click to see

 

Uludağ MO, Çalışkan Ergün B, Alkan DA, Ercan N, Özkan GY, Banoğlu E. Stable ester and amide conjugates of some NSAIDs as analgesic and antiinflammatory compounds with improved biological activity. Turk J Chem, 35, 427-439, 2011.

Click to see

2010

Ergün BC, Nuñez MT, Labeaga L, Ledo F, Darlington J, Bain G, Cakir B, Banoglu E. Synthesis of 1,5-diarylpyrazol-3-propanoic acids towards inhibition of cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4 formation.

Arzneimittelforschung. 60(8):497-505, 2010. Click to see

Eren G, Unlü S, Nuñez MT, Labeaga L, Ledo F, Entrena A, Banoglu E, Costantino G, Sahin MF. Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors. Bioorg

Med Chem. 18(17):6367-76, 2010. Click to see

 

Ilbasmiş-Tamer S, Yilmaz S, Banoğlu E, Değim IT. Carbon nanotubes to deliver drug molecules. J Biomed Nanotechnol. 6(1), 20-7, 2010. Click to see

 

Önkol T, Banoglu E, Dündar Y, Küpeli E, Şahin MF. Amide derivatives of [6-acyl-2-benzothiazolinon-3-yl] acetic acids as potential analgesic and antiinflammatory compounds. Med. Chem. Res. 19(1), 11-24, 2010. Click to see

2009

Dündar Y, Unlü S, Banoğlu E, Entrena A, Costantino G, Nuñez MT, Labeaga L, Sahin MF, Noyanalpan N. Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors. Eur J Med Chem. 44(5), 1830-7, 2009. Click to see

2008

Caliskan-Ergün B, Süküroğlu M, Coban T, Banoğlu E, Süzen S. Screening and evaluation of antioxidant activity of some pyridazine derivatives. J Enzyme Inhib Med Chem. 23(2), 225-9, 2008. Click to see

2007

Unlu S, Banoglu E, Ito S, Niiya T, Eren G, Ökçelik B, Şahin MF. Synthesis, characterization and preliminary screening of regioisomeric 1-(3-pyridazinyl)-3-arylpyrazole and 1-(3-pyridazinyl)-5-arylpyrazole derivatives towards cyclooxygenase inhibition. J Enzyme Inhib Med Chem. 22(3), 351-61, 2007. Click to see

2006

Sukuroglu M, Kupeli E, Banoglu E, Unlu S, Yesilada E, Sahin MF. Synthesis and analgesic activity of some 4,6-disubstituted-3(2H)-pyridazinone derivatives. Arzneim-Forsch/Drug Res. 56(5), 337-45, 2006. Click to see

2005

Banoglu E, Akoğlu Ç, Unlü S, Çalışkan Ergün B, Küpeli E, Yeşilada E, Şahin MF. Synthesis of Amide derivatives of [6-(3,5-dimethylpyrazole-1-yl)-3(2H)- pyridazinone-2-yl]acetic acids and Their Analgesic and Anti-inflammatory properties. Arzneim-Forsch/Drug Res. 55(9), 520-27, 2005. Click to see

Süküroglu M, Çalışkan Ergün B, Unlü S, Şahin MF, Küpeli E, Yeşilada E, Banoglu E. Synthesis, Analgesic and Anti-Inflammatory Activities of [6-(3,5-Dimethyl-4-chloro-pyrazole-1-yl)-3(2H)-pyridazinon-2-yl]acetamides. Arch. Pharm. Res. 28(5), 509-17, 2005. Click to see

2004

Banoglu E, Akoğlu Ç, Unlü S, Küpeli E, Yeşilada E, Şahin MF. Amide derivatives of [6-(5-methyl-3-phenylpyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acids as potential analgesic and anti-inflammatory compounds. Arch Pharm Pharm Med Chem. 337, 7-14, 2004. Click to see

2003

Gülcan HO, Unlü S, Banoglu E, Küpeli E, Yeşilada E, Şahin MF. Synthesis of New 4-(5-Chloro-2-oxo-3H-benzoxazol-3-yl)butanamide Derivatives and their Analgesic and Anti-inflammatory Properties. Turk J Chem. 27, 467-476, 2003.

Click to see

 

Ökçelik B, Unlü S, Banoglu E, Küpeli E, Yeşilada E, Şahin MF. Investigations on new pyridazinone derivatives for the synthesis of potent analgesic and antiinflammatory compounds with cyclooxygenase inhibition. Arch Pharm Pharm

Med Chem. 336, 406-412, 2003. Click to see

 

Banoglu E, Okçelik B, Kupeli E, Unlü S, Yeşilada E, Amat M, Caturla JF, M. Sahin MF. Amide Derivatives of [5-Chloro-6-(2-chloro/fluorobenzoyl)-2-benzoxazolinone-3-yl]acetic acids as Potential Analgesic and Anti-inflammatory Compounds. Arch Pharm Pharm Med Chem. 336, 251-257, 2003. Click to see

2002

Banoglu E, King RS. Sulfation of indoxyl by human and rat aryl (phenol) sulfotransferases to form indoxyl sulfate. Eur J Drug Met Pharm. 27(2):135-140, 2002. Click to see

2001

Banoglu E, Jha GG, King RS. Hepatic microsomal metabolism of indole to indoxyl, a precursor of indoxyl sulfate. Eur J Drug Met Pharm. 26(4):235-240, 2001. Click to see

 

Erk N, Özkan Y, Banoglu E, Özkan SA, Şentürk Z. Simultaneous determination of paracetamol and methocarbamol in tablets by ratio spectra derivative spectrophotometry and LC. J Pharm Biomed Anal. 24:469-475, 2001. Click to see

 

2000

Banoglu E, Özkan Y, Atay O. Dissolution tests of benazepril-HCl and hydrochlorothiazide in commercial tablets: Comparison of spectroscopic and HPLC methods. Farmaco 55:477-483, 2000. Click to see

Banoglu E. Current status of the cytosolic sulfotransferases in the metabolic activation of promutagens and procarcinogens Curr Drug Metab. 1:1-30, 2000. Click to see

1999

Tanyel FC, Aydin A, Banoglu E, Isimer A, Buyukpamukcu N. Noradrenaline and nitrite-nitrate concentrations in the contralateral testes during ipsilateral spermatic cord torsion in the presence or absence of a testis and epididymis.

Brit J Urology 83:833-836, 1999. Click to see

Banoglu E, Duffel MW. Importance of peri-Interactions on the stereospecificity of rat hydroxysteroid sulfotransferase STa with 1-arylethanols. Chem Res Toxicol. 12:278-285, 1999. Click to see

1998

Shibutani S, Dasaradhi L, Terashima I, Banoglu E, Duffel MW. Alphahydroxytamoxifen is a substrate of hydroxysteroid (alcohol) sulfotransferase, resulting in tamoxifen DNA adducts. Cancer Res. 58:4, 647-653, 1998. Click to see

1997

Banoglu E, Duffel MW. Studies on the Interactions of Chiral Secondary Alcohols with rat Hydroxysteroid

Sulfotransferase STa. Drug Metab Dispos. 25:1304-1310, 1997. Click to see

1995

Chen G, Banoglu E, Duffel MW. Influence of Substrate Structure on the Catalytic Efficiency of Hydroxysteroid Sulfotransferase STa in the Sulfation of Alcohols. Chem Res Toxicol. 9(1), 67-74, 1995. Click to see

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